In this view, the biochemical behavior of malignancies need not involve the presence of “embryonic cell rests” of another tissue, or the de novo formation of new enzymes, but simply an abnormally high concentration of certain enzymes normally present in small amounts. Thus, the concept is emerging that these tissues have, to a great degree, the same set of biosynthetic enzymes, but differ in the relative activities or amounts of different individual enzymes. ![]() Present developments of enzyme chemistry point toward a qualitative similarity of the biosynthetic systems in all tissues forming steroid hormones ( Samuels 1958). The embryological origin of these tissues from adjacent portions of the dorsal mesentery provided a plausible background for similarities ( Poll 1900, Politzer 1937, Gruenwald 1942). The production of sex hormones by congenital hyperplasias or malignancies of the adrenal cortex has long been recognized as suggestive of a biochemical relationship between the adrenal cortex and the gonads.
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